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Recombination in Bacteria

Jan 27, 2017• Category: Biology

In 1946, J. Lederberg and E. L. Tatum first demonstrated that genetic information can be exchanged between different mutant bacterial strains. This corresponds...

Isolation of Mutant Bacteria

Jan 12, 2017• Category: Biology

Important advances in genetics were made in the early 1950s through studies of bacteria. As prokaryotic organisms, bacteria have certain advantages over...

Xeroderma Pigmentosum

Jan 4, 2017• Category: Biology

Xeroderma pigmentosum (XP) is a heterogeneous group of genetically determined skin disorders due to unusual sensitivity to ultraviolet light. They are...

DNA repair

DNA Repair

Jan 4, 2017• Category: Biology

Life would not be possible without the ability to repair damaged DNA. Since replication errors, including mismatch, and harmful exogenous factors are everyday...

Trinucleotide Repeat Expansion

Jan 4, 2017• Category: Biology

The human genome contains tandem repeats of trinucleotides. Normally they occur in groups of 5–35 repeats. When their number exceeds a certain threshold and...

Transposition

Jan 3, 2017• Category: Biology

Aside from homologous recombination, the overall stability of the genome is interrupted by mobile sequences called transposable elements or transposons. There...

Recombinant DNA

Recombination

Dec 30, 2016• Category: Biology

Recombination lends the genome flexibility. Without genetic recombination, the genes on each individual chromosome would remain fixed in their particular...

DNA Polymorphism

Dec 30, 2016• Category: Biology

Genetic polymorphism is the existence of variants with respect to a gene locus (alleles), a chromosome structure(e.g., sizeofcentromeric heterochromatin), a...

DNA mutation

Mutation Due to Different Base Modifications

Dec 29, 2016• Category: Biology

Mutations can result from chemical or physical events that lead to base modification. When they affect the base-pairing pattern, they interfere with...

DNA mutation

Changes in DNA (Mutations)

Dec 26, 2016• Category: Biology

When it was recognized that changes (mutations) in genes occur spontaneously (T. H. Morgan, 1910) and can be induced by X-rays (H. J. Muller, 1927), the...

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